Uric Acid

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In humans and higher primates , uric acid actually hydrogen urate ion is the final oxidation breakdown product of purine metabolism and is excreted in urine, whereas in most other mammals , the enzyme uricase further oxidizes uric acid to allantoin. In humans, over half the antioxidant capacity of blood plasma comes from hydrogen urate ion. The Dalmatian dog has a genetic defect in uric acid uptake by the liver and kidneys , resulting in decreased conversion to allantoin, so this breed excretes uric acid, and not allantoin, in the urine.

Birds and reptiles. In birds and reptiles , and in some desert dwelling mammals such as the kangaroo rat , uric acid also is the end-product of purine metabolism, but it is excreted in feces as a dry mass. This involves a complex metabolic pathway that is energetically costly in comparison to processing of other nitrogenous wastes such as urea from the urea cycle or ammonia , but has the advantages of reducing water loss and preventing dehydration.

Platynereis dumerilii , a marine polychaete worm, uses uric acid as a sexual pheromone.

Gout - Mayo Clinic

The female of the species releases uric acid into the water during mating , to induce males to release sperm. A proportion of people have mutations in the proteins responsible for the excretion of uric acid by the kidneys. In human blood plasma , the reference range of uric acid is typically 3. Likewise, uric acid concentrations in urine above and below normal are known as hyperuricosuria and hypouricosuria.

Uric acid levels in saliva may be associated with blood uric acid levels. Hyperuricemia high levels of uric acid , which induces gout , has various potential origins:. Excess blood uric acid can induce gout , [34] a painful condition resulting from needle-like crystals of uric acid precipitating in joints , capillaries , skin , and other tissues.

Graphical abstract

In humans, purines are metabolized into uric acid which is then excreted in the urine. Consumption of some types of purine-rich foods, particularly meat and seafood, increases gout risk. One treatment for gout in the 19th century was administration of lithium salts; [38] lithium urate is more soluble. Today, inflammation during attacks is more commonly treated with NSAIDs , colchicine, or corticosteroids , and urate levels are managed with allopurinol. Tumor lysis syndrome , an emergency condition that may result from blood cancers , produces high uric acid levels in blood when tumor cells release their contents into the blood, either spontaneously or following chemotherapy.

Lesch-Nyhan syndrome , a rare inherited disorder, is also associated with high serum uric acid levels.

URIC ACID, SERUM

Hyperuricemia may increase risk factors for cardiovascular disease. Hyperuricemia may be a consequence of insulin resistance in diabetes rather than its precursor. Kidney stones can form through deposits of sodium urate microcrystals. Saturation levels of uric acid in blood may result in one form of kidney stones when the urate crystallizes in the kidney.

These uric acid stones are radiolucent and so do not appear on an abdominal plain X-ray. Low uric acid hypouricemia can have numerous causes. Low dietary zinc intakes cause lower uric acid levels. This effect can be even more pronounced in women taking oral contraceptive medication. Meta-analysis of 10 case-control studies found that the serum uric acid levels of patients with Multiple sclerosis were significantly lower compared to those of healthy controls, possibly indicating a diagnostic biomarker for multiple sclerosis.

Correcting low or deficient zinc levels can help elevate serum uric acid. From Wikipedia, the free encyclopedia. Uric acid. CAS Number. Beilstein Reference. PubChem CID.

Chemical formula. Solubility in water.

uric acid serum in other Cities

Heat capacity C. Std molar entropy S o This article lacks ISBNs for the books listed in it. Please make it easier to conduct research by listing ISBNs. August Marks; Colleen M. Request Appointment. Symptoms High uric acid level. Definition Causes When to see a doctor. Products and services. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sign up now.

Causes By Mayo Clinic Staff. References Uric acid. Lab Tests Online. Accessed Oct. Questions and answers about gout.

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Uric Acid in Blood

Kim SY, et al. Hyperuricemia and coronary heart disease: A systematic review and meta-analysis. Ohno, I. Relationship between hyperuricemia and chronic kidney disease. Nucleosides, Nucleotides and Nucleic Acids. Many conditions can change uric acid levels. Your doctor will talk with you about any abnormal results that may be related to your symptoms and past health. Gabica MD - Family Medicine. Author: Healthwise Staff.

Blood Test: Uric Acid (for Parents) - KidsHealth

Medical Review: Anne C. Uric Acid in Blood. Skip Navigation. Test Overview The blood uric acid test measures the amount of uric acid in a blood sample. Check to see if kidney stones may be caused by high uric acid levels in the body. Check to see if medicine that decreases uric acid levels is working. Check uric acid levels in people who are undergoing chemotherapy or radiation therapy. These treatments destroy cancer cells that then may leak uric acid into the blood.

How To Prepare You do not need to do anything before you have this test.

How It Is Done The health professional who takes a sample of your blood will: Wrap an elastic band around your upper arm to stop the flow of blood. This makes the veins below the band larger so it is easier to put a needle into the vein. Clean the needle site with alcohol. Put the needle into the vein. More than one needle stick may be needed. Attach a tube to the needle to fill it with blood.