Beating Lyme: Understanding and Treating This Complex and Often Misdiagnosed Disease

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Although this approach requires much more study, the FDA recently approved the use of pregabalin a related drug for the treatment of fibromyalgia. Other therapeutic possibilities are suggested from the unanticipated beneficial effects e.

For example, ceftriaxone, which is often used to treat chronic Lyme disease, has profound neuroprotective effects 6 , 7. Although not yet documented in controlled trials, such effects could ameliorate neurological symptoms, and some investigators are even contemplating clinical trials to determine whether ceftriaxone might be beneficial in treating patients with neurodegenerative diseases such as MS or amyotrophic lateral sclerosis. Perhaps these pharmacological effects, rather than elimination of a presumed persistent infection, might account for the short-lived benefits sometimes noted when antibiotics are used to treat chronic Lyme disease.


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If so, perhaps drugs other than antibiotics might be more suitable and effective for that purpose. I agree with the authors that improved diagnosis and prompt antibiotic therapy offer the best chance for success in curing early acute Lyme disease and avoiding further complications. However, with respect to chronic Lyme disease, it is time to discard the notion that it is due to a persistent infection and begin to examine other possibilities.

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Surely we owe at least that much to these patients. Go to JCI Insight. Top References Version history. First published September 2, - Version history. Klempner, M.

Beating Lyme: Understanding and Treating This Complex and Often Misdiagnosed Disease

Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. View this article via: PubMed Google Scholar. Version 1 September 2, : No description.

Lyme Disease Diagnosis and Treatment Options - Nicole Forsberg, NP-C, Lyme Disease Treatment Expert

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Contesting Lyme Disease - Oxford Handbooks

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